Modern plasma fractionation plants are complex engineering masterpiece: built to efficiently manage the fractionation of millions of liters of plasma applied in the formulation of a wide variety of therapeutic products.

This impressive process plant is no far behind: built with a Modular Approach for easier construction and installation. A plant in which each element is designed to handle organic material and therefore the process in an aseptic manner, ensuring compliance with the stringent requirements for the finished product; the technological washing and sterilization components play a fundamental role.

Such process plants can be enriched and made even more functional with an automatic or semi-automatic control system to supervise each process and maintenance phases, monitoring critical and non-critical parameters, guiding the operator during the production.

The Fractionation Plant is composed of 12 modules on Skid. The vessels provided are vertical tanks with jacket, built with the structure “Half coil/Tank in tank”, stainless-steel AISI 316L (product contact part), PED-tested, broken down as follows: two thawing 5.500 L tanks; two solvent/detergent 3.500 L tanks; ULF 1 8.000 L and ULF 2 1.200L tanks; pre-filter chromatography 3.500 L tank; two eluate 3.500 L tanks; three buffer concentrate 4.000 L tanks; benzyl alcohol 1.500 L tank. EPDM gaskets seal the space between the tanks and the platform, to separate clean area from non-clean one.

14 transfer panel equipped with min. 6/max. 20 connections – as per customer’s URS – allow the transport of the fluids.

TCM are installed to allow a perfect control of multiple temperature expected in process phases. 

Lastly, a system composed of three CIP cleans and sterilizes the whole plant.